By H. P. F. Koppeschaar, Torsten Tuvemo, Peter Trainer, Philip Zeitler
Read Online or Download 38th International Symposium on Growth Hormone and Growth Factors in Endocrinology and Metabolism: Granada, Spain, April 7-8, 2006 (Hormone Research) PDF
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Extra info for 38th International Symposium on Growth Hormone and Growth Factors in Endocrinology and Metabolism: Granada, Spain, April 7-8, 2006 (Hormone Research)
However, free IGF-I concentrations were elevated in both groups receiving GH; they increased by around 50% in the low-dose GH group and by 100% in the standarddose group. The effects of low-dose GH therapy on glucose homeostasis and insulin sensitivity were striking. 5 mmol/l below baseline, throughout the entire 12-month study period. There was no change in fasting glucose levels in the standard-dose group or the untreated controls (fig. 1). 0 Baseline 1 3 6 Time (months) 9 12 Fig. 1. Changes in fasting glucose levels over 12 months with LGH (low GH dose; j), SGH (standard titrating GH dose; +) and in untreated controls (d).
This plenary session presented opposing views regarding the impact of GH on glucose metabolism. L. Jørgensen of Aarhus University Hospital, Aarhus, Denmark, argues the case that GH does not improve glucose metabolism. GH induction of insulin resistance during periods of fasting is associated with enhanced lipid oxidation and protein conservation, constituting an apparently favorable metabolic adaptation. In addition, GH replacement seems to afford safe glycemic control when administered according to standard regimens.
Bone resorption markers (such as N- or C-telopeptide fragments of type I collagen) are usually measured, with a decrease in the need for antiresorptive therapy of more than 30–50% probably indicating a favourable response . It is also possible that monitoring may Eastell improve subjects’ long-term adherence with the treatment regimen . The major challenge in the field of osteoporosis is to identify those subjects at high risk of fracture and to treat them appropriately. There are groups of subjects who are likely to need treatment, such as subjects attending a fracture clinic or those receiving long-term glucocorticoid therapy.
38th International Symposium on Growth Hormone and Growth Factors in Endocrinology and Metabolism: Granada, Spain, April 7-8, 2006 (Hormone Research) by H. P. F. Koppeschaar, Torsten Tuvemo, Peter Trainer, Philip Zeitler