By H.A. Delemarre-van de Waal, P.-E. Mullis
This ebook on abnormalities in puberty offers an outline at the most modern wisdom at the mechanisms of the developmental methods of puberty. even supposing the precise mechanisms of reawakening of the GnRH pulse generator on the onset of puberty nonetheless must be elucidated, many genetic and environmental components were pointed out to play an immense function. subject matters mentioned in person chapters contain the endocrine and metabolic matters regarding the 'developmental beginning of grownup disorder' speculation and polycystic ovary syndrome in addition to abnormalities in GnRH controlling genes, GnRH-secreting hamartoma as a version for the onset of puberty, adventure at the program of GnRH analogues within the therapy of critical precocious puberty, and the psychosocial results of an early puberty. This quantity offers the paediatrician, endocrinologist, gynaecologist and healthcare professional with underlying details in addition to sensible tokens on how one can deal with some of the stipulations of a disturbed technique of puberty.
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Both testes were dissected and weights were recorded. Blood was collected via cardiac puncture and serum was stored at Ϫ20ЊC until assayed for testosterone and leptin. Leydig Cell Counts Leydig cells were measured according a previously described procedure  of the mouse Leydig cell assay (MLCA). 1% BSA. After 10 min stirring for detaching the Leydig cells, the mixture was filtered through monodur polyamide gauze (mesh size 100 m, Stokvis & Smits, IJmuiden, the Netherlands). The filtrate was centrifuged during 10 min at 150 g, the cells were resuspended in 3 ml fresh medium and counted in a Burker counting chamber.
J Clin Endocrinol Metab 1994;79:1355–1360. Ibanez L, Valls C, Ferrer A, Marcos MV, Rodriquez-Hierro F, de Zegher F: Sensitization to insulin induces ovulation in nonobese adolescents with anovulatory hyperandrogenism. J Clin Endocrinol Metab 2001;86:3595–3598. Koivunen R, Laatikkainen T, Tomas C, Huhtaniemi I, Tapanainen J, Martikainen H: The prevalence of polycystic ovaries in healthy women. Acta Obstet Gynecol Scand 1999;78:137–141. Ibanez L, Potau N, Enriquez G, de Zegher F: Reduced uterine and ovarian size in adolescent girls small for gestational age.
The defect is likely to be at the adrenal rather than pituitary level, as cortisol levels are low with normal or elevated ACTH levels , and cortisol responses to ACTH are poor [10, 12]. Contributory factors include degree of prematurity, as levels of cortisol, free cortisol and dehydroepiandrosterone sulfate (DHEAS) rise with increasing gestational age . Elevated 11-deoxycortisol to cortisol ratios suggest that activity of 11␤-hydroxylase, a key enzyme in cortisol biosynthesis, may be deficient in infants born Ͻ30 weeks’ gestation .
Abnormalities in puberty : scientific and clinical advances by H.A. Delemarre-van de Waal, P.-E. Mullis