By Derek Leroith

ISBN-10: 0762301589

ISBN-13: 9780762301584

Traditionally the sphere of endocrine examine has continually been on the vanguard of clinical endeavors. The investigators of those vital breakthroughs in learn were rewarded by means of a number of Nobel awards. within the box of diabetes by myself, Nobel prizes were provided to researchers who chanced on insulin, characterised the protein and invented radioimmunoassays utilizing insulin as a paradigm. no longer strangely, biomedical researchers have continually been attracted by way of the endocrine method and different comparable platforms of intercellular verbal exchange. during the last twenty years, endocrine examine has constructed quickly and tailored smooth molecular and mobile biology thoughts for its particular use. those adjustments have allowed researchers within the box to take care of their part. therefore, endocrine disease-related genes were characterised and mutations in those genes have helped clarify universal and much less universal endocrine issues. Our knowing of the rules of gene expression has been enormously more desirable via molecular innovations. In an try to convey investigators modern with the new advances during this exploding box we now have determined to post a sequence entitled Advances in Molecular and mobile Endocrinology. the world over recognized investigators have agreed to take part and their contributions are liked. quantity 1 has desirous about points of the hypothalamic-pituitary axis together with GnRH and GH gene rules, molecular features of insulin, insulin-like development components and glucagon. moreover, stories at the lately cloned calcium receptor and steroid receptor interactions with DNA are provided.

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Additional info for Advances in Molecular and Cellular Endocrinology, Vol. 1

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Mol. Cell. Biol. 10, 6596-6606. L. (1995). A neuron-specific enhancer targets expression of the gonadotropin-releasing hormone gene to hypothalamic neurosecretory neurons. Mol. Endocrinol. 9, 467-477. K. (1995). Regulation of gonadotropin-releasing hormone (GnRH) gene expression in hypothalamic neuronal cells. Cell. Mol. Neurobiol. 15, 79-88. H. (1990). A nonerythroid GATA-binding protein is required for function of the human preproendothelin-1 promoter in endothelial cells. Mol. Cell. Biol. 10, 4854-4862.

1993). Ion channel properties and episodic activity in isolated immortalized gonadotropin-releasing hormone (GnRH) neurons. J. Membr. Biol. 136, 85-96. , & Franchimont, P. (1989a). Direct activation of gonadotropin-releasing hormone secretion through different receptors to neuroexcitatory amino acids. Neuroendocrinology 49, 402-408. , & Franchimont, P. (1989b). Pulsatile release of gonadotropin-releasing hormone from hypothalamic explants is restrained by blockade of N-methyl-D,L-aspartate receptors.

M. (1993). Ion channel properties and episodic activity in isolated immortalized gonadotropin-releasing hormone (GnRH) neurons. J. Membr. Biol. 136, 85-96. , & Franchimont, P. (1989a). Direct activation of gonadotropin-releasing hormone secretion through different receptors to neuroexcitatory amino acids. Neuroendocrinology 49, 402-408. , & Franchimont, P. (1989b). Pulsatile release of gonadotropin-releasing hormone from hypothalamic explants is restrained by blockade of N-methyl-D,L-aspartate receptors.

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Advances in Molecular and Cellular Endocrinology, Vol. 1 by Derek Leroith


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