By M. Balestrino
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Extra info for Advances in the Preclinical Study of Ischemic Stroke
2010). Resveratrol protects against oxidized LDL-induced breakage of the blood-brain barrier by lessening disruption of tight junctions and apoptotic insults to mouse cerebrovascular endothelial cells. J Nutr 140 (12): 2187-2192. Love, S. (1999). Oxidative stress in brain ischemia. Brain Pathol 9 (1): 119-131. C. & Xia, Q. (2008). Inhibition of superoxide anion-mediated impairment of endothelium by treatment with luteolin and apigenin in rat mesenteric artery. Life Sci 83 (3-4): 110-117. , Morand.
A special feature of the sheep stroke model is the control of lesion size and subsequent behavioral deficits by occlusion of the cortical MCA or a defined number of its branches. A protocol for testing and quantification of neurological functions is available to assess the impact of the MCAO modality and a potential therapeutic procedure. Moreover, the model is eligible for detailed MR, CT and positron emission tomography (PET) studies as well as the assessment of autologous cell therapies. 2. Stereotaxy and cell tracking for stroke-related applications Stereotaxic concepts were developed as minimally invasive surgical approaches which use three-dimensional Cartesian or polar coordinate systems to localize small targets inside the 24 Advances in the Preclinical Study of Ischemic Stroke body.
Kato, T. & Yamori Y. (1997b). Faulty induction of blood-brain barrier functions by astrocytes isolated from stroke-prone spontaneously hypertensive rats. Clin Exp Pharmacol Physiol 24 (9-10): 686-691. , Tagami, M. & Yamori, Y. (2008). Nitric oxide reduces astrocytic lactate production and induces neuronal vulnerability in stroke-prone spontaneously hypertensive rats. Glia 56 (4): 387-393. Yamagata, K. , Tagawa, C. & Tagami, M. (2009). Vitamin E regulates SMase activity, GSH levels, and inhibits neuronal death in stroke-prone spontaneously hypertensive rats during hypoxia and reoxygenation.
Advances in the Preclinical Study of Ischemic Stroke by M. Balestrino