By Eduardo Sobarzo-sanchez

ISBN-10: 1634820754

ISBN-13: 9781634820752

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Extra info for Alkaloids : biosynthesis, biological roles and health benefits

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Boldine does not cause death in the mammalians even at high doses. According to animal studies, orally administration of boldine at 15 g kills a 12 kg dog [43]. Therefore, it can be concluded that 500 and 1000 mg/kg of body weight are maximum non-fatal doses of boldine for mice and guinea pigs [65]. There are no scientific reports about genotoxicity and/or carcinogenicity of boldine [66]. In addition, oral administration of boldine-rich extract at 3000 mg/kg of body weight causes no toxicity in rats [67].

Haikel, and M. Hassan, Vinblastine-induced apoptosis of Targeting Mitochondrial Bioenergetics of Cancer Cells with Alkaloids 33 melanoma cells is mediated by Ras homologous A protein (Rho A) via mitochondrial and non-mitochondrial-dependent mechanisms. Apoptosis, 18 (2013) 980-97. [169] W. Chiu, S. Luo, C. Chen, J. Cheng, C. Hsieh, C. Wang, W. Huang, W. Su, and C. Lin, Vinca alkaloids cause aberrant ROS-mediated JNK activation, Mcl-1 downregulation, DNA damage, mitochondrial dysfunction, and apoptosis in lung adenocarcinoma cells.

Baker, P. Quinlan, K. Robertson, S. Bray, G. Thomson, D. Kellock, L. Jordan, C. Purdie, D. Hardie, S. Fleming, and A. Thompson, Histological evaluation of AMPK signalling in primary breast cancer. BMC Cancer, 9 (2009). [69] K. A. Brown, N. U. Samarajeewa, and E. R. Simpson, Endocrine-related cancers and the role of AMPK. Mol. Cell. , 366 (2013) 170-9. [70] D. R. Alessi, K. Sakamoto, and J. R. Bayascas, LKB1-dependent signaling pathway s. Annu. Rev. , 75 (2006) 137-63. [71] M. Tiainen, K. Vaahtomeri, A.

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Alkaloids : biosynthesis, biological roles and health benefits by Eduardo Sobarzo-sanchez

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